| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NTAN1 (1-310) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NTAN1 |
| Gene ID: |
123803 |
| Uniprot ID: |
NTAN1_HUMAN |
| Immunogen Region: |
1-310 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human NTAN1 (NP_775745.1). |
| Immunogen Sequence: |
MPLLVEGRRVRLPQSAGDLV RAHPPLEERARLLRGQSVQQ VGPQGLLYVQQRELAVTSPK DGSISILGSDDATTCHIVVL RHTGNGATCLTHCDGTDTKA EVPLIMNSIKSFSDHAQCGR LEVHLVGGFSDDRQLSQKLT HQLLSEFDRQEDDIHLVTLC VTELNDREENENHFPVIYGI AVNIKTAEIYRASFQDRGPE EQLRAARTLAGGPMISIYDA ETEQLRIGPYSWTPFPHVD |
| Function | N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn. |
| Protein Name | Protein N-Terminal Asparagine AmidohydrolaseProtein Nh2-Terminal Asparagine AmidohydrolasePnaaProtein Nh2-Terminal Asparagine DeamidasePnadProtein N-Terminal Asn AmidaseProtein N-Terminal Asparagine AmidaseProtein Ntn-Amidase |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Protein N-Terminal Asparagine Amidohydrolase antibodyAnti-Protein Nh2-Terminal Asparagine Amidohydrolase antibodyAnti-Pnaa antibodyAnti-Protein Nh2-Terminal Asparagine Deamidase antibodyAnti-Pnad antibodyAnti-Protein N-Terminal Asn Amidase antibodyAnti-Protein N-Terminal Asparagine Amidase antibodyAnti-Protein Ntn-Amidase antibodyAnti-NTAN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
