Anti-NSP-C antibody [RNL-4] (STJ16100222)

Anti-NSP-C antibody [RNL-4] (STJ16100222)

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STJ16100222-100
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Short Description :Mouse monoclonal anti-NSP-C for use in FC, ICC, IHC-F, IHC-P and WB in Human, Rat and Swine samples. Datasheet included with dilution recommendations, and related reagents.
Applications:FC/ICC/IHC-F/IHC-P/WB
Host:Mouse
Reactivity:Human/Rat/Swine
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :RNL-4
Isotype:IgG1
Conjugation:Unconjugated
Concentration:1 mg/mL
Dilution Range:FC 1:50-1:100
ICC
IHC-F 1:100
IHC-p 1:100
WB 1:100-1:500
Formulation:PBS with 0.09% sodium azide
Storage Instruction:Store at 2-8°C for up to 1-year, upon receipt.
Immunogen:synthetic peptide encompassing the unique 20 N-terminal amino acid sequence of Reticulon-1C
Background In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is sofar not found in Human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).RNL-4 reacts with peripheral nerves and ganglia of various tissues and cross-reacts with smooth muscle cells and myoepithelium. In the central nervous system it reacts with the neurohypophysis and pars intermedia of the pituitary gland, and a weak diffuse staining was observed in neurons of the granular and molecular layer of the cerebellar cortex, while glial cells, cerebellar medulla and Purkinje cells are negative. Reticulon-1 has been found to indicate neuronal differentiation and to be downregulated in neurological pathologies.

Information sourced from Uniprot.org

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