![Anti-NSP-C antibody [RNL-4] (STJ16100222)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/148940/346564/STJ16100222_1__94501.1681998627.png?c=1 "Anti-NSP-C antibody [RNL-4] (STJ16100222)")
![Anti-NSP-C antibody [RNL-4] (STJ16100222)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/148940/346565/STJ16100222_2__60103.1681998628.png?c=1 "Anti-NSP-C antibody [RNL-4] (STJ16100222)")
![Anti-NSP-C antibody [RNL-4] (STJ16100222)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/148940/346564/STJ16100222_1__94501.1681998627.png?c=1 "Anti-NSP-C antibody [RNL-4] (STJ16100222)")
Anti-NSP-C antibody [RNL-4] (STJ16100222)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
Immunogensynthetic peptide encompassing the unique 20 N-terminal amino acid sequence of Reticulon-1C
General Information
| Short Description | Mouse monoclonal anti-NSP-C for use in FC, ICC, IHC-F, IHC-P and WB in Human, Rat and Swine samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/ICC/IHC-F/IHC-P/WB |
| Host | Mouse |
| Reactivity | Human/Rat/Swine |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RNL-4 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Dilution Range | FC 1:50-1:100ICCIHC-F 1:100IHC-p 1:100WB 1:100-1:500 |
| Formulation | PBS with 0.09% sodium azide |
| Storage Instruction | Store at 2-8ยฐC for up to 1-year, upon receipt. |
Target Information
| Immunogen | synthetic peptide encompassing the unique 20 N-terminal amino acid sequence of Reticulon-1C |
Additional Info
| Background | In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is sofar not found in Human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).RNL-4 reacts with peripheral nerves and ganglia of various tissues and cross-reacts with smooth muscle cells and myoepithelium. In the central nervous system it reacts with the neurohypophysis and pars intermedia of the pituitary gland, and a weak diffuse staining was observed in neurons of the granular and molecular layer of the cerebellar cortex, while glial cells, cerebellar medulla and Purkinje cells are negative. Reticulon-1 has been found to indicate neuronal differentiation and to be downregulated in neurological pathologies. |
Information sourced from Uniprot.org