Anti-NSMF antibody (STJA0009506)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human NELF
General Information
| Short Description | Rabbit polyclonal anti-NMDA receptor synaptonuclear signaling and neuronal migration factor for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NSMF |
| Gene ID | 26012 |
| Uniprot ID | NSMF_HUMAN |
| Immunogen | Synthesized peptide derived from human NELF |
| Specificity | This antibody detects endogenous levels of NELF at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Proteolytically processed after NMDA receptor activation. Cleaved in a calcium-dependent and calpain-sensitive manner. Calpain cleavage is essential for the translocation process from dendrites to the nucleus. |
| Function | Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells. |
| Protein Name | Nmda Receptor Synaptonuclear Signaling And Neuronal Migration FactorNasal Embryonic Luteinizing Hormone-Releasing Hormone FactorNasal Embryonic Lhrh Factor |
| Database Links | |
| Cellular Localisation | NucleusNucleus EnvelopeNucleus MembraneNucleus MatrixCytoplasmCell CortexCytoskeletonCell MembranePeripheral Membrane ProteinCell ProjectionDendriteSynapseSynaptosomePostsynaptic DensityMembraneFound On The Outside Of The Luteinizing-Hormone-Releasing Hormone (Lhrh) Cell Membrane And Axons Projecting From The Olfactory Pit And EpitheliumAssociates With Transcriptionally Active Chromatin RegionsDetected At The Nuclear Membranes Of Ca1 NeuronsCortical CytoskeletonLocalized In Proximal Apical DendritesColocalizes With Cabp1 In Dendrites And Dendritic SpinesMyristoylation Is A Prerequisite For Extranuclear LocalizationTranslocates From Dendrites To The Nucleus During Nmda Receptor-Dependent Long-Term Potentiation (Ltp) Induction Of Synaptic Transmission At Schaffer Collateral/Ca1 Synapses Of Hippocampal Primary Neurons And In A Importin-Dependent Manner |
| Alternative Antibody Names | Anti-Nmda Receptor Synaptonuclear Signaling And Neuronal Migration Factor antibodyAnti-Nasal Embryonic Luteinizing Hormone-Releasing Hormone Factor antibodyAnti-Nasal Embryonic Lhrh Factor antibodyAnti-NSMF antibodyAnti-NELF antibody |
Information sourced from Uniprot.org