| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-NMDA receptor synaptonuclear signaling and neuronal migration factor is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NSMF |
| Gene ID: | 26012 |
| Uniprot ID: | NSMF_HUMAN |
| Specificity: | This antibody detects endogenous levels of NELF at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human NELF |
| Post Translational Modifications | Proteolytically processed after NMDA receptor activation. Cleaved in a calcium-dependent and calpain-sensitive manner. Calpain cleavage is essential for the translocation process from dendrites to the nucleus. |
| Function | Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells. |
| Protein Name | Nmda Receptor Synaptonuclear Signaling And Neuronal Migration Factor Nasal Embryonic Luteinizing Hormone-Releasing Hormone Factor Nasal Embryonic Lhrh Factor |
| Cellular Localisation | Nucleus Nucleus Envelope Nucleus Membrane Nucleus Matrix Cytoplasm Cell Cortex Cytoskeleton Cell Membrane Peripheral Membrane Protein Cell Projection Dendrite Synapse Synaptosome Postsynaptic Density Membrane Found On The Outside Of The Luteinizing-Hormone-Releasing Hormone (Lhrh) Cell Membrane And Axons Projecting From The Olfactory Pit And Epithelium Associates With Transcriptionally Active Chromatin Regions Detected At The Nuclear Membranes Of Ca1 Neurons Cortical Cytoskeleton Localized In Proximal Apical Dendrites Colocalizes With Cabp1 In Dendrites And Dendritic Spines Myristoylation Is A Prerequisite For Extranuclear Localization Translocates From Dendrites To The Nucleus During Nmda Receptor-Dependent Long-Term Potentiation (Ltp) Induction Of Synaptic Transmission At Schaffer Collateral/Ca1 Synapses Of Hippocampal Primary Neurons And In A Importin-Dependent Manner |
| Alternative Antibody Names | Anti-Nmda Receptor Synaptonuclear Signaling And Neuronal Migration Factor antibody Anti-Nasal Embryonic Luteinizing Hormone-Releasing Hormone Factor antibody Anti-Nasal Embryonic Lhrh Factor antibody Anti-NSMF antibody Anti-NELF antibody |
Information sourced from Uniprot.org