Anti-NRBF2 antibody (140-189) (STJ94552)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human NRBF2. AA range:140-189
General Information
| Short Description | Rabbit polyclonal anti-Nuclear receptor-binding factor 2 (140-189) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NRBF2 |
| Gene ID | 29982 |
| Uniprot ID | NRBF2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NRBF2. AA range:140-189 |
| Immunogen Region | 140-189 |
| Specificity | NRBF-2 Polyclonal Antibody detects endogenous levels of NRBF-2 protein. |
Additional Info
| Tissue Specificity | Detected in keratinocytes, liver and placenta. Expressed in a subset of cells in pediatric medulloblastoma. |
| Function | May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation. |
| Protein Name | Nuclear Receptor-Binding Factor 2Nrbf-2Comodulator Of Ppar And Rxr |
| Database Links | Reactome: R-HSA-383280 |
| Cellular Localisation | NucleusCytoplasmCytoplasmic VesicleAutophagosome |
| Alternative Antibody Names | Anti-Nuclear Receptor-Binding Factor 2 antibodyAnti-Nrbf-2 antibodyAnti-Comodulator Of Ppar And Rxr antibodyAnti-NRBF2 antibodyAnti-COPR antibody |
Information sourced from Uniprot.org