| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Nuclear receptor-binding factor 2 (140-189) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NRBF2 |
| Gene ID: | 29982 |
| Uniprot ID: | NRBF2_HUMAN |
| Immunogen Region: | 140-189 |
| Specificity: | NRBF-2 Polyclonal Antibody detects endogenous levels of NRBF-2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human NRBF2. AA range:140-189 |
| Tissue Specificity | Detected in keratinocytes, liver and placenta. Expressed in a subset of cells in pediatric medulloblastoma. |
| Function | May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation. |
| Protein Name | Nuclear Receptor-Binding Factor 2 Nrbf-2 Comodulator Of Ppar And Rxr |
| Database Links | Reactome: R-HSA-383280 |
| Cellular Localisation | Nucleus Cytoplasm Cytoplasmic Vesicle Autophagosome |
| Alternative Antibody Names | Anti-Nuclear Receptor-Binding Factor 2 antibody Anti-Nrbf-2 antibody Anti-Comodulator Of Ppar And Rxr antibody Anti-NRBF2 antibody Anti-COPR antibody |
Information sourced from Uniprot.org