Anti-NR3C2 antibody (450-600) (STJ116199)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NR3C2 (450-600) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NR3C2 |
| Gene ID | 4306 |
| Uniprot ID | MCR_HUMAN |
| Immunogen Region | 450-600 |
| Immunogen Sequence | FPFMDGSYFSFMDDKDYYSL SGILGPPVPGFDGNCEGSGF PVGIKQEPDDGSYYPEASIP SSAIVGVNSGGQSFHYRIGA QGTISLSRSARDQSFQHLSS FPPVNTLVESWKSHGDLSSR RSDGYPVLEYIPENVSSSTL RSVSTGSSRPS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 450-600 of human Mineralocorticoid receptor (NR3C2) (NP_000892.2). |
Additional Info
| Tissue Specificity | Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes. |
| Post Translational Modifications | Phosphorylated. |
| Function | Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. |
| Protein Name | Mineralocorticoid ReceptorMrNuclear Receptor Subfamily 3 Group C Member 2 |
| Database Links | Reactome: R-HSA-3371497Reactome: R-HSA-383280Reactome: R-HSA-4090294 |
| Cellular Localisation | CytoplasmNucleusEndoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic And Nuclear In The Absence Of LigandNuclear After Ligand-BindingWhen Bound To Hsd11b2It Is Found Associated With The Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Mineralocorticoid Receptor antibodyAnti-Mr antibodyAnti-Nuclear Receptor Subfamily 3 Group C Member 2 antibodyAnti-NR3C2 antibodyAnti-MCR antibodyAnti-MLR antibody |
Information sourced from Uniprot.org