Anti-Npc1l1-Mouse antibody (C-Term) (STJ72542)

SKU:
STJ72542-100

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Host: Goat
Applications: Pep-ELISA
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-Npc1l1-Mouse (C-Term) is suitable for use in ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: ELISA-antibody detection limit dilution 1:16000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Immunogen Region: C-Term
Accession Number: NP_997125.2
Immunogen Sequence: SEPSCPQYPFPAD
Post Translational Modifications Highly glycosylated.
Function Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.
Protein Name Npc1-Like Intracellular Cholesterol Transporter 1
Niemann-Pick C1-Like Protein 1
Database Links Reactome: R-RNO-8963678
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Subfractionation Of Brush Border Membranes From Proximal Enterocytes Suggests Considerable Association With The Apical Membrane Fraction
Exists As A Predominantly Cell Surface Membrane Expressed Protein
Alternative Antibody Names Anti-Npc1-Like Intracellular Cholesterol Transporter 1 antibody
Anti-Niemann-Pick C1-Like Protein 1 antibody
Anti-Npc1l1 antibody

Information sourced from Uniprot.org

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