Anti-Npc1l1-Mouse antibody (C-Term) (STJ72542)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Npc1l1-Mouse (C-Term) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Preliminary experiments in Mouse and Rat Liver and Lung lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would appreciate any feedback fr |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Accession Number | NP_997125.2 |
| Immunogen Region | C-Term |
| Immunogen Sequence | SEPSCPQYPFPAD |
Additional Info
| Post Translational Modifications | Highly glycosylated. |
| Function | Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation. |
| Protein Name | Npc1-Like Intracellular Cholesterol Transporter 1Niemann-Pick C1-Like Protein 1 |
| Database Links | Reactome: R-RNO-8963678 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell MembraneSubfractionation Of Brush Border Membranes From Proximal Enterocytes Suggests Considerable Association With The Apical Membrane FractionExists As A Predominantly Cell Surface Membrane Expressed Protein |
| Alternative Antibody Names | Anti-Npc1-Like Intracellular Cholesterol Transporter 1 antibodyAnti-Niemann-Pick C1-Like Protein 1 antibodyAnti-Npc1l1 antibody |
Information sourced from Uniprot.org