• Immunohistochemistry of rat liver with Anti-NPC1 primary antibody (STJ501954) at 1:100 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 40X.

Anti-NPC1 antibody (1228-1278) (STJ501954)

SKU:
STJ501954-100

$596.03
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-NPC1 (1228-1278) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:4, 000
IP: 1:150
IHC: 1:100
ICC: 1:100
IF: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: NPC1
Gene ID: 4864
Uniprot ID: NPC1_HUMAN
Immunogen Region: 1228-1278
Immunogen: Synthetic peptide taken within amino acid region 1228-1278 on human Niemann-Pick C1 protein.
Post Translational Modifications N-glycosylated.
Function Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9. (Microbial infection) Acts as an endosomal entry receptor for ebolavirus.
Protein Name Npc Intracellular Cholesterol Transporter 1
Niemann-Pick C1 Protein
Database Links Reactome: R-HSA-8964038
Cellular Localisation Late Endosome Membrane
Multi-Pass Membrane Protein
Lysosome Membrane
Alternative Antibody Names Anti-Npc Intracellular Cholesterol Transporter 1 antibody
Anti-Niemann-Pick C1 Protein antibody
Anti-NPC1 antibody

Information sourced from Uniprot.org

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