Anti-NPAT antibody (629-679 aa) (STJ197587)

SKU:
STJ197587

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Protein NPAT (629-679 aa) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NPAT
Gene ID: 4863
Uniprot ID: NPAT_HUMAN
Immunogen Region: 629-679 aa
Specificity: This antibody detects endogenous levels of human NPAT
Immunogen: Synthesized peptide derived from the human NPAT at the amino acid range 629-679
Post Translational Modifications Phosphorylated at Ser-775, Ser-779, Ser-1100, Thr-1270 and Thr-1350 by CCNE1/CDK2 at G1-S transition and until prophase, which promotes association with histone gene clusters and stimulates activation of histone transcription. Also phosphorylated by CCNA1/CDK2 in vitro.
Function Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters.
Protein Name Protein Npat
Nuclear Protein Of The Ataxia Telangiectasia Mutated Locus
Nuclear Protein Of The Atm Locus
P220
Cellular Localisation Nucleus
Cajal Body
Concentrates In Two Cajal Bodies Tethered To Histone Gene Clusters At Chromosome 6p21 During G1
S And G2 Phases
Also Concentrates In Two Additional Cajal Bodies Tethered To Histone Gene Clusters At Chromosome 1q21 Specifically During S And G2 Phases
Alternative Antibody Names Anti-Protein Npat antibody
Anti-Nuclear Protein Of The Ataxia Telangiectasia Mutated Locus antibody
Anti-Nuclear Protein Of The Atm Locus antibody
Anti-P220 antibody
Anti-NPAT antibody
Anti-CAND3 antibody
Anti-E14 antibody

Information sourced from Uniprot.org

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