| Post Translational Modifications | Phosphorylated at Ser-775, Ser-779, Ser-1100, Thr-1270 and Thr-1350 by CCNE1/CDK2 at G1-S transition and until prophase, which promotes association with histone gene clusters and stimulates activation of histone transcription. Also phosphorylated by CCNA1/CDK2 in vitro. |
| Function | Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. |
| Protein Name | Protein NpatNuclear Protein Of The Ataxia Telangiectasia Mutated LocusNuclear Protein Of The Atm LocusP220 |
| Cellular Localisation | NucleusCajal BodyConcentrates In Two Cajal Bodies Tethered To Histone Gene Clusters At Chromosome 6p21 During G1S And G2 PhasesAlso Concentrates In Two Additional Cajal Bodies Tethered To Histone Gene Clusters At Chromosome 1q21 Specifically During S And G2 Phases |
| Alternative Antibody Names | Anti-Protein Npat antibodyAnti-Nuclear Protein Of The Ataxia Telangiectasia Mutated Locus antibodyAnti-Nuclear Protein Of The Atm Locus antibodyAnti-P220 antibodyAnti-NPAT antibodyAnti-CAND3 antibodyAnti-E14 antibody |
Information sourced from Uniprot.org
