| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NOSIP (1-301) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NOSIP |
| Gene ID: |
51070 |
| Uniprot ID: |
NOSIP_HUMAN |
| Immunogen Region: |
1-301 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-301 of human NOSIP (NP_057037.1). |
| Immunogen Sequence: |
MTRHGKNCTAGAVYTYHEKK KDTAASGYGTQNIRLSRDAV KDFDCCCLSLQPCHDPVVTP DGYLYEREAILEYILHQKKE IARQMKAYEKQRGTRREEQK ELQRAASQDHVRGFLEKESA IVSRPLNPFTAKALSGTSPD DVQPGPSVGPPSKDKDKVLP SFWIPSLTPEAKATKLEKPS RTVTCPMSGKPLRMSDLTPV HFTPLDSSVDRVGLITRSER YVCAVTRDSLSNATPCAVL |
| Tissue Specificity | Expressed in heart, brain and lung. Present in endothelial cells (at protein level). |
| Function | E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB. Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity. |
| Protein Name | Nitric Oxide Synthase-Interacting ProteinE3 Ubiquitin-Protein Ligase NosipRing-Type E3 Ubiquitin Transferase NosipEnos-Interacting Protein |
| Database Links | Reactome: R-HSA-203754 |
| Cellular Localisation | CytoplasmNucleusTranslocates From Nucleus To Cytoplasm In The G2 Phase Of The Cell Cycle |
| Alternative Antibody Names | Anti-Nitric Oxide Synthase-Interacting Protein antibodyAnti-E3 Ubiquitin-Protein Ligase Nosip antibodyAnti-Ring-Type E3 Ubiquitin Transferase Nosip antibodyAnti-Enos-Interacting Protein antibodyAnti-NOSIP antibodyAnti-CGI-25 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
