Anti-NOSIP antibody (1-301) (STJ112064)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NOSIP (1-301) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NOSIP |
| Gene ID | 51070 |
| Uniprot ID | NOSIP_HUMAN |
| Immunogen Region | 1-301 |
| Immunogen Sequence | MTRHGKNCTAGAVYTYHEKK KDTAASGYGTQNIRLSRDAV KDFDCCCLSLQPCHDPVVTP DGYLYEREAILEYILHQKKE IARQMKAYEKQRGTRREEQK ELQRAASQDHVRGFLEKESA IVSRPLNPFTAKALSGTSPD DVQPGPSVGPPSKDKDKVLP SFWIPSLTPEAKATKLEKPS RTVTCPMSGKPLRMSDLTPV HFTPLDSSVDRVGLITRSER YVCAVTRDSLSNATPCAVL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-301 of human NOSIP (NP_057037.1). |
Additional Info
| Tissue Specificity | Expressed in heart, brain and lung. Present in endothelial cells (at protein level). |
| Function | E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB. Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity. |
| Protein Name | Nitric Oxide Synthase-Interacting ProteinE3 Ubiquitin-Protein Ligase NosipRing-Type E3 Ubiquitin Transferase NosipEnos-Interacting Protein |
| Database Links | Reactome: R-HSA-203754 |
| Cellular Localisation | CytoplasmNucleusTranslocates From Nucleus To Cytoplasm In The G2 Phase Of The Cell Cycle |
| Alternative Antibody Names | Anti-Nitric Oxide Synthase-Interacting Protein antibodyAnti-E3 Ubiquitin-Protein Ligase Nosip antibodyAnti-Ring-Type E3 Ubiquitin Transferase Nosip antibodyAnti-Enos-Interacting Protein antibodyAnti-NOSIP antibodyAnti-CGI-25 antibody |
Information sourced from Uniprot.org