Anti-nNOS antibody (STJ13100503)
SPECIFICATIONS
ClonalityPolyclonal
HostGuinea Pig
ConjugationUnconjugated
ImmunogenA synthetic peptide from human nNOS conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse and shares 96% identity with rat's sequence.
General Information
| Short Description | Guinea Pig polyclonal anti-nNOS for use in IHC and WB in Human, Mouse, Rat and Marmoset samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Guinea Pig |
| Reactivity | Human/Mouse/Rat/Marmoset |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | IHC, WB. A dilution of 1: 500 is recommended. The optimal dilution should be determined by the end user. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Nos1 |
| Gene ID | 24598 |
| Uniprot ID | NOS1_RAT |
| Immunogen | A synthetic peptide from human nNOS conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse and shares 96% identity with rat's sequence. |
| Specificity | Specific for nNOS |
Additional Info
| Post Translational Modifications | Ubiquitinated.mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro). |
| Function | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. |
| Protein Name | Nitric Oxide Synthase 1Constitutive NosNc-NosNos Type INeuronal NosN-NosNnosNitric Oxide Synthase - BrainBnosPeptidyl-Cysteine S-Nitrosylase Nos1 |
| Database Links | Reactome: R-RNO-1222556Reactome: -RNO-392154Reactome: -RNO-5578775 |
| Cellular Localisation | Cell MembraneSarcolemmaPeripheral Membrane ProteinCell ProjectionDendritic SpineIn Skeletal MuscleIt Is Localized Beneath The Sarcolemma Of Fast-Twitch Muscle Fiber By Associating With The Dystrophin Glycoprotein ComplexIn NeuronsEnriched In Dendritic Spines |
| Alternative Antibody Names | Anti-Nitric Oxide Synthase 1 antibodyAnti-Constitutive Nos antibodyAnti-Nc-Nos antibodyAnti-Nos Type I antibodyAnti-Neuronal Nos antibodyAnti-N-Nos antibodyAnti-Nnos antibodyAnti-Nitric Oxide Synthase - Brain antibodyAnti-Bnos antibodyAnti-Peptidyl-Cysteine S-Nitrosylase Nos1 antibodyAnti-Nos1 antibodyAnti-Bnos antibody |
Information sourced from Uniprot.org