Anti-NLRP12 antibody (456-506 aa) (STJ195951)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human NAL12 at the amino acid range 456-506
General Information
| Short Description | Rabbit polyclonal anti-NACHT, LRR and PYD domains-containing protein 12 (456-506 aa) for use in WB, ELISA and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NLRP12 |
| Gene ID | 91662 |
| Uniprot ID | NAL12_HUMAN |
| Immunogen | Synthesized peptide derived from the human NAL12 at the amino acid range 456-506 |
| Immunogen Region | 456-506 aa |
| Specificity | This antibody detects endogenous levels of NAL12 at Human/Mouse |
Additional Info
| Function | Plays an essential role as an potent mitigator of inflammation. Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways. Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway. In turn, promotes bacterial tolerance. Also inhibits the RIGI-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation. Also acts as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue. |
| Protein Name | Nacht - Lrr And Pyd Domains-Containing Protein 12Monarch-1Pyrin-Containing Apaf1-Like Protein 7Regulated By Nitric Oxide |
| Database Links | Reactome: R-HSA-9705671 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Nacht - Lrr And Pyd Domains-Containing Protein 12 antibodyAnti-Monarch-1 antibodyAnti-Pyrin-Containing Apaf1-Like Protein 7 antibodyAnti-Regulated By Nitric Oxide antibodyAnti-NLRP12 antibodyAnti-NALP12 antibodyAnti-PYPAF7 antibodyAnti-RNO antibody |
Information sourced from Uniprot.org