Anti-NHP2 antibody (1-153) (STJ116289)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NHP2 (1-153) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NHP2 |
| Gene ID | 55651 |
| Uniprot ID | NHP2_HUMAN |
| Immunogen Region | 1-153 |
| Immunogen Sequence | MTKIKADPDGPEAQAEACSG ERTYQELLVNQNPIAQPLAS RRLTRKLYKCIKKAVKQKQI RRGVKEVQKFVNKGEKGIMV LAGDTLPIEVYCHLPVMCED RNLPYVYIPSKTDLGAAAGS KRPTCVIMVKPHEEYQEAYD ECLEEVQSLPLPL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-153 of human NHP2 (NP_060308.1). |
Additional Info
| Tissue Specificity | Expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Also expressed at lower levels in the liver. |
| Function | Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. |
| Protein Name | H/Aca Ribonucleoprotein Complex Subunit 2Nucleolar Protein Family A Member 2Snornp Protein Nhp2 |
| Database Links | Reactome: R-HSA-171319Reactome: R-HSA-6790901 |
| Cellular Localisation | NucleusNucleolusCajal BodyAlso Localized To Cajal Bodies (Coiled Bodies) |
| Alternative Antibody Names | Anti-H/Aca Ribonucleoprotein Complex Subunit 2 antibodyAnti-Nucleolar Protein Family A Member 2 antibodyAnti-Snornp Protein Nhp2 antibodyAnti-NHP2 antibodyAnti-NOLA2 antibodyAnti-HSPC286 antibody |
Information sourced from Uniprot.org