| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NHP2 (1-153) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NHP2 |
| Gene ID: |
55651 |
| Uniprot ID: |
NHP2_HUMAN |
| Immunogen Region: |
1-153 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-153 of human NHP2 (NP_060308.1). |
| Immunogen Sequence: |
MTKIKADPDGPEAQAEACSG ERTYQELLVNQNPIAQPLAS RRLTRKLYKCIKKAVKQKQI RRGVKEVQKFVNKGEKGIMV LAGDTLPIEVYCHLPVMCED RNLPYVYIPSKTDLGAAAGS KRPTCVIMVKPHEEYQEAYD ECLEEVQSLPLPL |
| Tissue Specificity | Expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Also expressed at lower levels in the liver. |
| Function | Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. |
| Protein Name | H/Aca Ribonucleoprotein Complex Subunit 2Nucleolar Protein Family A Member 2Snornp Protein Nhp2 |
| Database Links | Reactome: R-HSA-171319Reactome: R-HSA-6790901 |
| Cellular Localisation | NucleusNucleolusCajal BodyAlso Localized To Cajal Bodies (Coiled Bodies) |
| Alternative Antibody Names | Anti-H/Aca Ribonucleoprotein Complex Subunit 2 antibodyAnti-Nucleolar Protein Family A Member 2 antibodyAnti-Snornp Protein Nhp2 antibodyAnti-NHP2 antibodyAnti-NOLA2 antibodyAnti-HSPC286 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
