| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NFYB |
| Gene ID: | 4801 |
| Uniprot ID: | NFYB_HUMAN |
| Immunogen Region: | 1-207 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human NFYB (NP_006157.1). |
| Immunogen Sequence: | MTMDGDSSTTDASQLGISAD YIGGSHYVIQPHDDTEDSMN DHEDTNGSKESFREQDIYLP IANVARIMKNAIPQTGKIAK DAKECVQECVSEFISFITSE ASERCHQEKRKTINGEDILF AMSTLGFDSYVEPLKLYLQK FREAMKGEKGIGGAVTATDG LSEELTEEAFTNQLPAGLIT TDGQQQNVMVYTTSYQQISG VQQIQFS |
| Post Translational Modifications | Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of histone H3 methylations as well as histone H2B monoubiquitination at 'Lys-121'. |
| Function | Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. |
| Protein Name | Nuclear Transcription Factor Y Subunit BetaCaat Box Dna-Binding Protein Subunit BNuclear Transcription Factor Y Subunit BNf-Yb |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2426168Reactome: R-HSA-380994Reactome: R-HSA-381183Reactome: R-HSA-9614657 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Transcription Factor Y Subunit Beta antibodyAnti-Caat Box Dna-Binding Protein Subunit B antibodyAnti-Nuclear Transcription Factor Y Subunit B antibodyAnti-Nf-Yb antibodyAnti-NFYB antibodyAnti-HAP3 antibody |
Information sourced from Uniprot.org
