Anti-NFYB antibody (1-207) (STJ29434)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NFYB (1-207) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NFYB |
| Gene ID | 4801 |
| Uniprot ID | NFYB_HUMAN |
| Immunogen Region | 1-207 |
| Immunogen Sequence | MTMDGDSSTTDASQLGISAD YIGGSHYVIQPHDDTEDSMN DHEDTNGSKESFREQDIYLP IANVARIMKNAIPQTGKIAK DAKECVQECVSEFISFITSE ASERCHQEKRKTINGEDILF AMSTLGFDSYVEPLKLYLQK FREAMKGEKGIGGAVTATDG LSEELTEEAFTNQLPAGLIT TDGQQQNVMVYTTSYQQISG VQQIQFS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human NFYB (NP_006157.1). |
Additional Info
| Post Translational Modifications | Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of histone H3 methylations as well as histone H2B monoubiquitination at 'Lys-121'. |
| Function | Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. |
| Protein Name | Nuclear Transcription Factor Y Subunit BetaCaat Box Dna-Binding Protein Subunit BNuclear Transcription Factor Y Subunit BNf-Yb |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2426168Reactome: R-HSA-380994Reactome: R-HSA-381183Reactome: R-HSA-9614657 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Transcription Factor Y Subunit Beta antibodyAnti-Caat Box Dna-Binding Protein Subunit B antibodyAnti-Nuclear Transcription Factor Y Subunit B antibodyAnti-Nf-Yb antibodyAnti-NFYB antibodyAnti-HAP3 antibody |
Information sourced from Uniprot.org