Anti-Neurturin antibody (STJA0002881)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant human NRTN protein produced using CHO-based proprietary suspension cell line. Protein was purified from the cell culture supernatant. human Neurturin
General Information
| Short Description | Rabbit polyclonal anti-Neurturin for use in ELISA, WB and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/IF |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Immunogen affinity purification |
| Dilution Range | WB 0.2 to 1 µg/ml; ELISA 0.01 to 0.02 µg/ml; IF 0.5 to 2 µg/ml Antibody doesn t cross-react to other GDNF-family proteins Polyclonal antibody working titer has to be established practically for each particular antigen and assay format |
| Formulation | Concentrated ammonium sulphate in PBS pH 7.4 |
| Storage Instruction | Store at +4°C upon receipt. As product is (NH4) 2SO4 precipitate, mix well by pipetting or vortexing prior use |
Target Information
| Gene Symbol | NRTN |
| Gene ID | 4902 |
| Uniprot ID | NRTN_HUMAN |
| Immunogen | Recombinant human NRTN protein produced using CHO-based proprietary suspension cell line. Protein was purified from the cell culture supernatant. human Neurturin |
| Specificity | Human NRTN |
Additional Info
| Function | Growth factor that supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Involved in the development of the neural crest. Might control the size of non-neuronal cell population such as haemopoietic cells. Acts by binding to its coreceptor, GFRA2, leading to autophosphorylation and activation of the RET receptor. Heparan sulfate-binding is required for signaling. |
| Protein Name | Neurturin |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Neurturin antibodyAnti-NRTN antibody |
Information sourced from Uniprot.org