Anti-NEU4 antibody (STJA0007046)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human NEU4
General Information
| Short Description | Rabbit polyclonal anti-Sialidase-4 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NEU4 |
| Gene ID | 129807 |
| Uniprot ID | NEUR4_HUMAN |
| Immunogen | Synthesized peptide derived from human NEU4 |
| Specificity | This antibody detects endogenous levels of NEU4 at Human, Mouse |
Additional Info
| Post Translational Modifications | Isoform 2: N-glycosylated. |
| Function | Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons. May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation. Has sialidase activity toward mucin, fetuin and sialyllactose. |
| Protein Name | Sialidase-4N-Acetyl-Alpha-Neuraminidase 4 |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-9840310 Q8WWR8-2 |
| Cellular Localisation | Isoform 1: Cell MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneMicrosome MembraneMitochondrion MembraneCell ProjectionNeuron ProjectionPredominantly Associates With Endoplasmic Reticulum MembranesOnly A Small Fraction Associates With Mitochondrial And Plasma MembranesIsoform 2: Mitochondrion Inner MembraneMitochondrion Outer MembraneLysosome LumenIsoform 2 Is SolubleN-Glycosylated And Found In The Lumen Of LysosomesHoweverNo Signal Sequence Nor N-Glycosylation Site Is Predicted From The Sequence |
| Alternative Antibody Names | Anti-Sialidase-4 antibodyAnti-N-Acetyl-Alpha-Neuraminidase 4 antibodyAnti-NEU4 antibodyAnti-LP5125 antibody |
Information sourced from Uniprot.org