Anti-NEU4 antibody (STJA0007046)

SKU:
STJA0007046

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Sialidase-4 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NEU4
Gene ID: 129807
Uniprot ID: NEUR4_HUMAN
Specificity: This antibody detects endogenous levels of NEU4 at Human, Mouse
Immunogen: Synthesized peptide derived from human NEU4
Post Translational Modifications Isoform 2: N-glycosylated.
Function Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons. May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation. Has sialidase activity toward mucin, fetuin and sialyllactose.
Protein Name Sialidase-4
N-Acetyl-Alpha-Neuraminidase 4
Database Links Reactome: R-HSA-1660662 Q8WWR8-2
Reactome: R-HSA-4085001
Cellular Localisation Isoform 1: Cell Membrane
Peripheral Membrane Protein
Endoplasmic Reticulum Membrane
Microsome Membrane
Mitochondrion Membrane
Cell Projection
Neuron Projection
Predominantly Associates With Endoplasmic Reticulum Membranes
Only A Small Fraction Associates With Mitochondrial And Plasma Membranes
Isoform 2: Mitochondrion Inner Membrane
Mitochondrion Outer Membrane
Lysosome Lumen
Isoform 2 Is Soluble
N-Glycosylated And Found In The Lumen Of Lysosomes
However
No Signal Sequence Nor N-Glycosylation Site Is Predicted From The Sequence
Alternative Antibody Names Anti-Sialidase-4 antibody
Anti-N-Acetyl-Alpha-Neuraminidase 4 antibody
Anti-NEU4 antibody
Anti-LP5125 antibody

Information sourced from Uniprot.org

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