| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NET1 |
| Gene ID: | 10276 |
| Uniprot ID: | ARHG8_HUMAN |
| Immunogen Region: | 1-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NET1 (NP_001040625.1). |
| Immunogen Sequence: | MEPELAAQKQPRPRRRSRRA SGLSTEGATGPSADTSGSEL DGRCSLRRGSSFTFLTPGPN WDFTLKRKRREKDDDVVSLS SLDLKEPSNKRVRPLARVTS LANLISPVRNGAVRRFGQTI QSFTLRGDHRSPASAQKFSS RSTVPTPAKRRSSALWSEML DITMKESLTTREIRRQEAIY EMSRGEQDLIEDLKLARKAY HDPMLKLSIMSEEELTHIFG DLDSYIPLHEDLLTRIGEA |
| Tissue Specificity | Widely expressed. |
| Function | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. |
| Protein Name | Neuroepithelial Cell-Transforming Gene 1 ProteinProto-Oncogene P65 Net1Rho Guanine Nucleotide Exchange Factor 8 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013026 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Neuroepithelial Cell-Transforming Gene 1 Protein antibodyAnti-Proto-Oncogene P65 Net1 antibodyAnti-Rho Guanine Nucleotide Exchange Factor 8 antibodyAnti-NET1 antibodyAnti-ARHGEF8 antibody |
Information sourced from Uniprot.org
