Anti-NET1 antibody (1-300) (STJ24743)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NET1 (1-300) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NET1 |
| Gene ID | 10276 |
| Uniprot ID | ARHG8_HUMAN |
| Immunogen Region | 1-300 |
| Immunogen Sequence | MEPELAAQKQPRPRRRSRRA SGLSTEGATGPSADTSGSEL DGRCSLRRGSSFTFLTPGPN WDFTLKRKRREKDDDVVSLS SLDLKEPSNKRVRPLARVTS LANLISPVRNGAVRRFGQTI QSFTLRGDHRSPASAQKFSS RSTVPTPAKRRSSALWSEML DITMKESLTTREIRRQEAIY EMSRGEQDLIEDLKLARKAY HDPMLKLSIMSEEELTHIFG DLDSYIPLHEDLLTRIGEA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human NET1 (NP_001040625.1). |
Additional Info
| Tissue Specificity | Widely expressed. |
| Function | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. |
| Protein Name | Neuroepithelial Cell-Transforming Gene 1 ProteinProto-Oncogene P65 Net1Rho Guanine Nucleotide Exchange Factor 8 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013026 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Neuroepithelial Cell-Transforming Gene 1 Protein antibodyAnti-Proto-Oncogene P65 Net1 antibodyAnti-Rho Guanine Nucleotide Exchange Factor 8 antibodyAnti-NET1 antibodyAnti-ARHGEF8 antibody |
Information sourced from Uniprot.org