| Short Description : | Rabbit polyclonal anti-Serine/threonine-protein kinase Nek11 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NEK11 |
| Gene ID: | 79858 |
| Uniprot ID: | NEK11_HUMAN |
| Immunogen: | Synthesized peptide derived from human NEK11 |
| Specificity: | This antibody detects endogenous levels of NEK11 at Human, Mouse |
| Post Translational Modifications | Phosphorylated by NEK2. Phosphorylation at Ser-273 is important for its activation. |
| Function | Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. |
| Protein Name | Serine/Threonine-Protein Kinase Nek11Never In Mitosis A-Related Kinase 11Nima-Related Protein Kinase 11 |
| Database Links | |
| Cellular Localisation | NucleusNucleolusNuclear During Interphase But Moves To The Polar Microtubules During Prometaphase And MetaphaseAccumulates In The Nucleolus In G1/S-Arrested Cells |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Nek11 antibodyAnti-Never In Mitosis A-Related Kinase 11 antibodyAnti-Nima-Related Protein Kinase 11 antibodyAnti-NEK11 antibody |
Information sourced from Uniprot.org
