Anti-NEIL2 antibody (STJ190804)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Endonuclease 8-like 2 lyase Neil2 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NEIL2 |
| Gene ID | 252969 |
| Uniprot ID | NEIL2_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | NEIL2 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. |
| Protein Name | Endonuclease 8-Like 2Dna Glycosylase/Ap Lyase Neil2Dna-(Apurinic Or Apyrimidinic Site Lyase Neil2Endonuclease Viii-Like 2Nei Homolog 2Neh2Nei-Like Protein 2 |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-5649702 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Endonuclease 8-Like 2 antibodyAnti-Dna Glycosylase/Ap Lyase Neil2 antibodyAnti-Dna-(Apurinic Or Apyrimidinic Site Lyase Neil2 antibodyAnti-Endonuclease Viii-Like 2 antibodyAnti-Nei Homolog 2 antibodyAnti-Neh2 antibodyAnti-Nei-Like Protein 2 antibodyAnti-NEIL2 antibody |
Information sourced from Uniprot.org