| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Endonuclease 8-like 2 lyase Neil2 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NEIL2 |
| Gene ID: |
252969 |
| Uniprot ID: |
NEIL2_HUMAN |
| Specificity: |
NEIL2 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Function | Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. |
| Protein Name | Endonuclease 8-Like 2Dna Glycosylase/Ap Lyase Neil2Dna-(Apurinic Or Apyrimidinic Site Lyase Neil2Endonuclease Viii-Like 2Nei Homolog 2Neh2Nei-Like Protein 2 |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-5649702 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Endonuclease 8-Like 2 antibodyAnti-Dna Glycosylase/Ap Lyase Neil2 antibodyAnti-Dna-(Apurinic Or Apyrimidinic Site Lyase Neil2 antibodyAnti-Endonuclease Viii-Like 2 antibodyAnti-Nei Homolog 2 antibodyAnti-Neh2 antibodyAnti-Nei-Like Protein 2 antibodyAnti-NEIL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
