Anti-NECTIN4 antibody (32-146) (STJ118589)

Name: Anti-NECTIN4 antibody (32-146) (STJ118589)
SKU: STJ118589
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ118589

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Short Description	Rabbit polyclonal PVRL4 (32-146) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:1000-1:5000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	NECTIN4
Gene ID	81607
Uniprot ID	NECT4_HUMAN
Immunogen Region	32-146
Immunogen Sequence	GELETSDVVTVVLGQDAKLP CFYRGDSGEQVGQVAWARVD AGEGAQELALLHSKYGLHVS PAYEGRVEQPPPPRNPLDGS VLLRNAVQADEGEYECRVST FPAGSFQARLRLRVL
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 32-146 of human PVRL4 (NP_112178.2).

Tissue Specificity	Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.
Post Translational Modifications	The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.
Function	Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. (Microbial infection) Acts as a receptor for measles virus.
Protein Name	Nectin-4 Ig Superfamily Receptor Lnir Nectin Cell Adhesion Molecule 4 Poliovirus Receptor-Related Protein 4 Cleaved Into - Processed Poliovirus Receptor-Related Protein 4
Database Links	Reactome: R-HSA-418990 Reactome: R-HSA-420597
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Cell Junction Adherens Junction Colocalizes With Afdn At Cadherin-Based Adherens Junctions Processed Poliovirus Receptor-Related Protein 4: Secreted The Secreted Form Is Found In Breast Tumor Patients
Alternative Antibody Names	Anti-Nectin-4 antibody Anti-Ig Superfamily Receptor Lnir antibody Anti-Nectin Cell Adhesion Molecule 4 antibody Anti-Poliovirus Receptor-Related Protein 4 Cleaved Into - Processed Poliovirus Receptor-Related Protein 4 antibody Anti-NECTIN4 antibody Anti-LNIR antibody Anti-PRR4 antibody Anti-PVRL4 antibody

Information sourced from Uniprot.org