Anti-NCR3 antibody (19-201) (STJ29233)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NCR3 (19-201) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NCR3 |
| Gene ID | 259197 |
| Uniprot ID | NCTR3_HUMAN |
| Immunogen Region | 19-201 |
| Immunogen Sequence | LWVSQPPEIRTLEGSSAFLP CSFNASQGRLAIGSVTWFRD EVVPGKEVRNGTPEFRGRLA PLASSRFLHDHQAELHIRDV RGHDASIYVCRVEVLGLGVG TGNGTRLVVEKEHPQLG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 19-135 of human NCR3 (NP_667341.1). |
Additional Info
| Tissue Specificity | Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. |
| Function | Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. |
| Protein Name | Natural Cytotoxicity Triggering Receptor 3Activating Natural Killer Receptor P30Natural Killer Cell P30-Related ProteinNk-P30Nkp30Cd Antigen Cd337 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Natural Cytotoxicity Triggering Receptor 3 antibodyAnti-Activating Natural Killer Receptor P30 antibodyAnti-Natural Killer Cell P30-Related Protein antibodyAnti-Nk-P30 antibodyAnti-Nkp30 antibodyAnti-Cd Antigen Cd337 antibodyAnti-NCR3 antibodyAnti-1C7 antibodyAnti-LY117 antibody |
Information sourced from Uniprot.org