| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NCR3 |
| Gene ID: | 259197 |
| Uniprot ID: | NCTR3_HUMAN |
| Immunogen Region: | 19-201 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-135 of human NCR3 (NP_667341.1). |
| Immunogen Sequence: | LWVSQPPEIRTLEGSSAFLP CSFNASQGRLAIGSVTWFRD EVVPGKEVRNGTPEFRGRLA PLASSRFLHDHQAELHIRDV RGHDASIYVCRVEVLGLGVG TGNGTRLVVEKEHPQLG |
| Tissue Specificity | Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. |
| Function | Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. |
| Protein Name | Natural Cytotoxicity Triggering Receptor 3 Activating Natural Killer Receptor P30 Natural Killer Cell P30-Related Protein Nk-P30 Nkp30 Cd Antigen Cd337 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Natural Cytotoxicity Triggering Receptor 3 antibody Anti-Activating Natural Killer Receptor P30 antibody Anti-Natural Killer Cell P30-Related Protein antibody Anti-Nk-P30 antibody Anti-Nkp30 antibody Anti-Cd Antigen Cd337 antibody Anti-NCR3 antibody Anti-1C7 antibody Anti-LY117 antibody |
Information sourced from Uniprot.org