Anti-NCOR2 antibody (1-2514) (STJ110686)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NCOR2 (1-2514) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NCOR2 |
| Gene ID | 9612 |
| Uniprot ID | NCOR2_HUMAN |
| Immunogen Region | 1-2514 |
| Immunogen Sequence | MSGSTQPVAQTWRATEPRYP PHSLSYPVQIARTHTDVGLL EYQHHSRDYASHLSPGSIIQ PQRRRPSLLSEFQPGNERSQ ELHLRPESHSYLPELGKSEM EFIESKRPRLELL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-113 of human NCOR2 (NP_006303.4). |
Additional Info
| Tissue Specificity | Ubiquitous. High levels of expression are detected in lung, spleen and brain. |
| Function | Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3. Required to activate the histone deacetylase activity of HDAC3. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Isoform 1: Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Isoform 4: Isoform 1 and isoform 4 have different affinities for different nuclear receptors. |
| Protein Name | Nuclear Receptor Corepressor 2N-Cor2Ctg Repeat Protein 26Smap270Silencing Mediator Of Retinoic Acid And Thyroid Hormone ReceptorSmrtT3 Receptor-Associating FactorTracThyroid- - Retinoic-Acid-Receptor-Associated Corepressor |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2122947Reactome: R-HSA-2173795Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-3214815Reactome: R-HSA-350054Reactome: R-HSA-381340Reactome: R-HSA-383280Reactome: R-HSA-3899300Reactome: R-HSA-400206Reactome: R-HSA-9022537Reactome: R-HSA-9022692Reactome: R-HSA-9029569Reactome: R-HSA-9609690Reactome: R-HSA-9623433Reactome: R-HSA-9707564Reactome: R-HSA-9841922 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Corepressor 2 antibodyAnti-N-Cor2 antibodyAnti-Ctg Repeat Protein 26 antibodyAnti-Smap270 antibodyAnti-Silencing Mediator Of Retinoic Acid And Thyroid Hormone Receptor antibodyAnti-Smrt antibodyAnti-T3 Receptor-Associating Factor antibodyAnti-Trac antibodyAnti-Thyroid- - Retinoic-Acid-Receptor-Associated Corepressor antibodyAnti-NCOR2 antibodyAnti-CTG26 antibody |
Information sourced from Uniprot.org