| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-NCOR2 (1-2514) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NCOR2 |
| Gene ID: | 9612 |
| Uniprot ID: | NCOR2_HUMAN |
| Immunogen Region: | 1-2514 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-2514 of human NCOR2 (NP_006303.4). |
| Immunogen Sequence: | MSGSTQPVAQTWRATEPRYP PHSLSYPVQIARTHTDVGLL EYQHHSRDYASHLSPGSIIQ PQRRRPSLLSEFQPGNERSQ ELHLRPESHSYLPELGKSEM EFIESKRPRLELL |
| Tissue Specificity | Ubiquitous. High levels of expression are detected in lung, spleen and brain. |
| Function | Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. |
| Protein Name | Nuclear Receptor Corepressor 2N-Cor2Ctg Repeat Protein 26Smap270Silencing Mediator Of Retinoic Acid And Thyroid Hormone ReceptorSmrtT3 Receptor-Associating FactorTracThyroid- - Retinoic-Acid-Receptor-Associated Corepressor |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2122947Reactome: R-HSA-2173795Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-3214815Reactome: R-HSA-350054Reactome: R-HSA-381340Reactome: R-HSA-383280Reactome: R-HSA-3899300Reactome: R-HSA-400206Reactome: R-HSA-9022537Reactome: R-HSA-9022692Reactome: R-HSA-9029569Reactome: R-HSA-9609690Reactome: R-HSA-9623433Reactome: R-HSA-9707564 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Corepressor 2 antibodyAnti-N-Cor2 antibodyAnti-Ctg Repeat Protein 26 antibodyAnti-Smap270 antibodyAnti-Silencing Mediator Of Retinoic Acid And Thyroid Hormone Receptor antibodyAnti-Smrt antibodyAnti-T3 Receptor-Associating Factor antibodyAnti-Trac antibodyAnti-Thyroid- - Retinoic-Acid-Receptor-Associated Corepressor antibodyAnti-NCOR2 antibodyAnti-CTG26 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
