||Human, Rat, Mouse, Monkey, Canine
||FOR RESEARCH USE ONLY (RUO).
||Goat polyclonal antibody anti-Nucleolin (500aa C-Term) is suitable for use in Western Blot research applications.
||PBS, 20% Glycerol and 0.05% Sodium Azide.
||This antibody is epitope-affinity purified from goat antiserum.
||For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours.
||Detects endogenous levels of NCL by Western blot.
||Purified recombinant peptide derived from within residues 500 aa to the C-terminus of human NCL produced in E. coli.
| Post Translational Modifications || Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group. Symmetrically methylated by PRMT5. |
| Function || Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. |
| Protein Name || NucleolinProtein C23 |
| Database Links || Reactome: R-HSA-6791226 |
| Cellular Localisation || NucleusNucleolusCytoplasmLocalized In Cytoplasmic Mrnp Granules Containing Untranslated Mrnas |
| Alternative Antibody Names || Anti-Nucleolin antibodyAnti-Protein C23 antibodyAnti-NCL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance