| Post Translational Modifications | Phosphorylated on Ser and Tyr residues. Phosphorylated in response to activation of EGFR and FcERI. Phosphorylated by activated PDGFRB. |
| Function | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. |
| Protein Name | Sh2/Sh3 Adapter Protein Nck1Cytoplasmic Protein Nck1Nck Adapter Protein 1Nck-1Sh2/Sh3 Adapter Protein Nck-Alpha |
| Database Links | Reactome: R-HSA-186763Reactome: R-HSA-202433Reactome: R-HSA-2029482Reactome: R-HSA-373753Reactome: R-HSA-418885Reactome: R-HSA-428540Reactome: R-HSA-4420097Reactome: R-HSA-5663213Reactome: R-HSA-9013420Reactome: R-HSA-9013424Reactome: R-HSA-9664422Reactome: R-HSA-9679191Reactome: R-HSA-9833482Reactome: R-HSA-983695 |
| Cellular Localisation | CytoplasmEndoplasmic ReticulumNucleusMostly CytoplasmicBut Shuttles Between The Cytoplasm And The NucleusImport Into The Nucleus Requires The Interaction With Socs7Predominantly Nuclear Following Genotoxic StressesSuch As Uv IrradiationHydroxyurea Or Mitomycin C Treatments |
| Alternative Antibody Names | Anti-Sh2/Sh3 Adapter Protein Nck1 antibodyAnti-Cytoplasmic Protein Nck1 antibodyAnti-Nck Adapter Protein 1 antibodyAnti-Nck-1 antibodyAnti-Sh2/Sh3 Adapter Protein Nck-Alpha antibodyAnti-NCK1 antibodyAnti-NCK antibody |
Information sourced from Uniprot.org
