| Host: | Rabbit |
| Applications: | IHC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Soss Complex Subunit B2 is suitable for use in Immunohistochemistry and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Purification: | Antigen affinity purification |
| Concentration: | 1.38 mg/mL |
| Dilution Range: | IHC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: | NABP1 |
| Gene ID: | 64859 |
| Uniprot ID: | SOSB2_HUMAN |
| Immunogen: | Fusion protein of human NABP1 |
| Function | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. |
| Protein Name | Soss Complex Subunit B2 Nucleic Acid-Binding Protein 1 Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2a Sensor Of Single-Strand Dna Complex Subunit B2 Sensor Of Ssdna Subunit B2 Soss-B2 Single-Stranded Dna-Binding Protein 2 Hssb2 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | Nucleus Localizes To Nuclear Foci Following Dna Damage |
| Alternative Antibody Names | Anti-Soss Complex Subunit B2 antibody Anti-Nucleic Acid-Binding Protein 1 antibody Anti-Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2a antibody Anti-Sensor Of Single-Strand Dna Complex Subunit B2 antibody Anti-Sensor Of Ssdna Subunit B2 antibody Anti-Soss-B2 antibody Anti-Single-Stranded Dna-Binding Protein 2 antibody Anti-Hssb2 antibody Anti-NABP1 antibody Anti-OBFC2A antibody Anti-SSB2 antibody |
Information sourced from Uniprot.org