Anti-MYSM1 antibody (720-821) (STJ24674)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MYSM1 (720-821) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MYSM1 |
| Gene ID | 114803 |
| Uniprot ID | MYSM1_HUMAN |
| Immunogen Region | 720-821 |
| Immunogen Sequence | SYRLPYKFEVQQMLEEPQWG LVFEKTRWIIEKYRLSHSSV PMDKIFRRDSDLTCLQKLLE CMRKTLSKVTNCFMAEEFLT EIENLFLSNYKSNQENGVTE EN |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 720-821 of human MYSM1 (NP_001078956.1). |
Additional Info
| Function | Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity. Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes. Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component. Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains. In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors. Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome. |
| Protein Name | Deubiquitinase Mysm12a-DubMyb-Like - Swirm And Mpn Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-5689901 |
| Cellular Localisation | NucleusCytoplasmLocalizes To The Cytoplasm In Response To Bacterial Infection |
| Alternative Antibody Names | Anti-Deubiquitinase Mysm1 antibodyAnti-2a-Dub antibodyAnti-Myb-Like - Swirm And Mpn Domain-Containing Protein 1 antibodyAnti-MYSM1 antibodyAnti-KIAA1915 antibody |
Information sourced from Uniprot.org