| Function | Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity. Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes. Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component. Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains. In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors. Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome. |
| Protein Name | Deubiquitinase Mysm12a-DubMyb-Like - Swirm And Mpn Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-5689901 |
| Cellular Localisation | NucleusCytoplasmLocalizes To The Cytoplasm In Response To Bacterial Infection |
| Alternative Antibody Names | Anti-Deubiquitinase Mysm1 antibodyAnti-2a-Dub antibodyAnti-Myb-Like - Swirm And Mpn Domain-Containing Protein 1 antibodyAnti-MYSM1 antibodyAnti-KIAA1915 antibody |
Information sourced from Uniprot.org
