| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MYSM1 (720-821) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MYSM1 |
| Gene ID: |
114803 |
| Uniprot ID: |
MYSM1_HUMAN |
| Immunogen Region: |
720-821 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 720-821 of human MYSM1 (NP_001078956.1). |
| Immunogen Sequence: |
SYRLPYKFEVQQMLEEPQWG LVFEKTRWIIEKYRLSHSSV PMDKIFRRDSDLTCLQKLLE CMRKTLSKVTNCFMAEEFLT EIENLFLSNYKSNQENGVTE EN |
| Function | Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity. Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes. Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component. Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains. In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors. Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome. |
| Protein Name | Deubiquitinase Mysm12a-DubMyb-Like - Swirm And Mpn Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-5689901 |
| Cellular Localisation | NucleusCytoplasmLocalizes To The Cytoplasm In Response To Bacterial Infection |
| Alternative Antibody Names | Anti-Deubiquitinase Mysm1 antibodyAnti-2a-Dub antibodyAnti-Myb-Like - Swirm And Mpn Domain-Containing Protein 1 antibodyAnti-MYSM1 antibodyAnti-KIAA1915 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
