Anti-MYBPC3 antibody (200-400) (STJ114230)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MYBPC3 (200-400) antibody for use in WB, IHC-P and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MYBPC3 |
| Gene ID | 4607 |
| Uniprot ID | MYPC3_HUMAN |
| Immunogen Region | 200-400 |
| Immunogen Sequence | SSKVGQHLQLHDSYDRASKV YLFELHITDAQPAFTGSYRC EVSTKDKFDCSNFNLTVHEA MGTGDLDLLSAFRRTSLAGG GRRISDSHEDTGILDFSSLL KKRDSFRTPRDSKLEAPAEE DVWEILRQAPPSEYERIAFQ YGVTDLRGMLKRLKGMRRDE KKSTAFQKKLEPAYQVSKGH KIRLTVELADHDAEVKWLKN G |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 200-400 of human MYBPC3 (NP_000247.2). |
Additional Info
| Post Translational Modifications | Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate contraction. Polyubiquitinated. |
| Function | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. |
| Protein Name | Myosin-Binding Protein C - Cardiac-TypeCardiac Mybp-CC-Protein - Cardiac Muscle Isoform |
| Database Links | Reactome: R-HSA-390522 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Myosin-Binding Protein C - Cardiac-Type antibodyAnti-Cardiac Mybp-C antibodyAnti-C-Protein - Cardiac Muscle Isoform antibodyAnti-MYBPC3 antibody |
Information sourced from Uniprot.org