| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MYBBP1A |
| Gene ID: | 10514 |
| Uniprot ID: | MBB1A_HUMAN |
| Immunogen Region: | 1104-1328 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1104-1328 of human MYBBP1A (NP_055335.2). |
| Immunogen Sequence: | DLTVLLGVLQGQQQSLQQGA HSTGSSRLHDLYWQAMKTLG VQRPKLEKKDAKEIPSATQS PISKKRKKKGFLPETKKRKK RKSEDGTPAEDGTPAATGGS QPPSMGRKKRNRTKAKVPAQ ANGTPTTKSPAPGAPTRSPS TPAKSPKLQKKNQKPSQVNG APGSPTEPAGQKQHQKALPK KGVLGKSPLSALARKKARLS LVIRSPSLLQSGAKKKAQVR KAGKP |
| Post Translational Modifications | Citrullinated by PADI4. |
| Function | May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter. Has a role in rRNA biogenesis together with PWP1. |
| Protein Name | Myb-Binding Protein 1a |
| Database Links | Reactome: R-HSA-5250924 |
| Cellular Localisation | CytoplasmNucleusNucleolusShuttles Between The Nucleus And CytoplasmNuclear Import May Be Mediated By Kpna2While Export Appears To Depend Partially On Xpo1/Crm1Predominantly Nucleolar |
| Alternative Antibody Names | Anti-Myb-Binding Protein 1a antibodyAnti-MYBBP1A antibodyAnti-P160 antibody |
Information sourced from Uniprot.org