Anti-MYBBP1A antibody (1104-1328) (STJ24653)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MYBBP1A (1104-1328) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MYBBP1A |
| Gene ID | 10514 |
| Uniprot ID | MBB1A_HUMAN |
| Immunogen Region | 1104-1328 |
| Immunogen Sequence | DLTVLLGVLQGQQQSLQQGA HSTGSSRLHDLYWQAMKTLG VQRPKLEKKDAKEIPSATQS PISKKRKKKGFLPETKKRKK RKSEDGTPAEDGTPAATGGS QPPSMGRKKRNRTKAKVPAQ ANGTPTTKSPAPGAPTRSPS TPAKSPKLQKKNQKPSQVNG APGSPTEPAGQKQHQKALPK KGVLGKSPLSALARKKARLS LVIRSPSLLQSGAKKKAQVR KAGKP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1104-1328 of human MYBBP1A (NP_055335.2). |
Additional Info
| Post Translational Modifications | Citrullinated by PADI4. |
| Function | May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter. Has a role in rRNA biogenesis together with PWP1. |
| Protein Name | Myb-Binding Protein 1a |
| Database Links | Reactome: R-HSA-5250924 |
| Cellular Localisation | CytoplasmNucleusNucleolusShuttles Between The Nucleus And CytoplasmNuclear Import May Be Mediated By Kpna2While Export Appears To Depend Partially On Xpo1/Crm1Predominantly Nucleolar |
| Alternative Antibody Names | Anti-Myb-Binding Protein 1a antibodyAnti-MYBBP1A antibodyAnti-P160 antibody |
Information sourced from Uniprot.org