Anti-MUTYH antibody (476aa C-Term) (STJ140046)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
ImmunogenPurified recombinant peptide derived from within residues 476 aa to the C-terminus of human Mutyh produced in E. coli.
General Information
| Short Description | Goat polyclonal MutY homolog (E. coli) (476aa C-Term) antibody for use in WB in human, mouse, rat, bovine, canine, chicken, avian, donkey, feline, goat, guinea pig, hamster, horse, porcine, rabbit, sheep and simian samples. Datasheet included with di |
| Applications | WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Bovine/Canine/Chicken/Avian/Donkey/Feline/Goat/Guinea Pig/Hamster/Horse/Porcine/Rabbit/Sheep/Simian |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 3 mg/mL |
| Purification | This antibody is epitope-affinity purified from goat antiserum. |
| Dilution Range | WB 1:500-1:2000Ferreira JV Rosa Soares A Ramalho JS et al. PLoS One. 2019 Oct. PMID: 31613922 |
| Formulation | PBS, 20% Glycerol and 0.05% Sodium Azide. |
| Storage Instruction | For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours. |
Target Information
| Gene Symbol | MUTYH |
| Gene ID | 4595 |
| Uniprot ID | MUTYH_HUMAN |
| Accession Number | ENSG00000132781 |
| Immunogen | Purified recombinant peptide derived from within residues 476 aa to the C-terminus of human Mutyh produced in E. coli. |
| Immunogen Region | 476aa C-Term |
| Immunogen Sequence | MKKVFRVYQGQQPGTCMGSK KKVFRVYQGQQPGTCMGSKR KVFRVYQGQQPGTCMGSKRS |
| Specificity | In 293HEK cells transfected with cds plasmid (myc-his-Mutyh) detects a band of 50 kDa by Western blot. |
Additional Info
| Function | Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities. |
| Protein Name | Adenine Dna GlycosylaseMuty HomologHmyh |
| Database Links | Reactome: R-HSA-110330Reactome: R-HSA-110331Reactome: R-HSA-110357Reactome: R-HSA-9608287 Q9UIF7-3Reactome: R-HSA-9608290 |
| Cellular Localisation | NucleusMitochondrion |
| Alternative Antibody Names | Anti-Adenine Dna Glycosylase antibodyAnti-Muty Homolog antibodyAnti-Hmyh antibodyAnti-MUTYH antibodyAnti-MYH antibody |
Information sourced from Uniprot.org