Anti-MUT antibody (451-750) (STJ24646)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MUT (451-750) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MMUT |
| Gene ID | 4594 |
| Uniprot ID | MUTA_HUMAN |
| Immunogen Region | 451-750 |
| Immunogen Sequence | EMGGMAKAVAEGIPKLRIEE CAARRQARIDSGSEVIVGVN KYQLEKEDAVEVLAIDNTSV RNRQIEKLKKIKSSRDQALA ERCLAALTECAASGDGNILA LAVDASRARCTVGEITDALK KVFGEHKANDRMVSGAYRQE FGESKEITSAIKRVHKFMER EGRRPRLLVAKMGQDGHDRG AKVIATGFADLGFDVDIGPL FQTPREVAQQAVDADVHAVG ISTLAAGHKTLVPELIKEL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 451-750 of human MUT (NP_000246.2). |
Additional Info
| Function | Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. |
| Protein Name | Methylmalonyl-Coa Mutase - MitochondrialMcmMethylmalonyl-Coa Isomerase |
| Database Links | Reactome: R-HSA-3359475Reactome: R-HSA-3359478Reactome: R-HSA-71032Reactome: R-HSA-9759218 |
| Cellular Localisation | Mitochondrion MatrixMitochondrionCytoplasm |
| Alternative Antibody Names | Anti-Methylmalonyl-Coa Mutase - Mitochondrial antibodyAnti-Mcm antibodyAnti-Methylmalonyl-Coa Isomerase antibodyAnti-MMUT antibodyAnti-MUT antibody |
Information sourced from Uniprot.org