![Anti-MUM1 antibody [MRQ-8] (STJ16100401)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149118/346739/STJ16100401_1__79751.1681998831.jpg?c=1 "Anti-MUM1 antibody [MRQ-8] (STJ16100401)")
![Anti-MUM1 antibody [MRQ-8] (STJ16100401)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149118/346739/STJ16100401_1__79751.1681998831.jpg?c=1 "Anti-MUM1 antibody [MRQ-8] (STJ16100401)")
| Host: | Mouse |
| Applications: | IHC-P |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-MUM1 is suitable for use in Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | MRQ-8 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Dilution Range: | IHC 1:100 – 1:500 |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Gene Symbol: | IRF4 |
| Gene ID: | 3662 |
| Uniprot ID: | IRF4_HUMAN |
| Tissue Specificity | Lymphoid cells. |
| Post Translational Modifications | Phosphorylation by ROCK2 regulates IL-17 and IL-21 production. |
| Function | Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes. |
| Protein Name | Interferon Regulatory Factor 4 Irf-4 Lymphocyte-Specific Interferon Regulatory Factor Lsirf Multiple Myeloma Oncogene 1 Nf-Em5 |
| Database Links | Reactome: R-HSA-6785807 Reactome: R-HSA-877300 Reactome: R-HSA-909733 Reactome: R-HSA-9725371 Reactome: R-HSA-9824585 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Interferon Regulatory Factor 4 antibody Anti-Irf-4 antibody Anti-Lymphocyte-Specific Interferon Regulatory Factor antibody Anti-Lsirf antibody Anti-Multiple Myeloma Oncogene 1 antibody Anti-Nf-Em5 antibody Anti-IRF4 antibody Anti-MUM1 antibody |
Information sourced from Uniprot.org