| Short Description : | Rabbit polyclonal anti-DNA mismatch repair protein Msh3 (51-100) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MSH3 |
| Gene ID: | 4437 |
| Uniprot ID: | MSH3_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human MSH3. AA range:51-100 |
| Immunogen Region: | 51-100 |
| Specificity: | MSH3 Polyclonal Antibody detects endogenous levels of MSH3 protein. |
| Function | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. |
| Protein Name | Dna Mismatch Repair Protein Msh3Hmsh3Divergent Upstream ProteinDupMismatch Repair Protein 1Mrp1 |
| Database Links | Reactome: R-HSA-5358606Reactome: R-HSA-5632927Reactome: R-HSA-5632928 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Dna Mismatch Repair Protein Msh3 antibodyAnti-Hmsh3 antibodyAnti-Divergent Upstream Protein antibodyAnti-Dup antibodyAnti-Mismatch Repair Protein 1 antibodyAnti-Mrp1 antibodyAnti-MSH3 antibodyAnti-DUC1 antibodyAnti-DUG antibody |
Information sourced from Uniprot.org
