| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MRI1 |
| Gene ID: |
84245 |
| Uniprot ID: |
MTNA_HUMAN |
| Immunogen Region: |
1-369 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-369 of human MRI1 (NP_001026897.1). |
| Immunogen Sequence: |
MTLEAIRYSRGSLQILDQLL LPKQSRYEAVGSVHQAWEAI RAMKVRGAPAIALVGCLSLA VELQAGAGGPGLAALVAFVR DKLSFLVTARPTAVNMARAA RDLADVAAREAEREGATEEA VRERVICCTEDMLEKDLRDN RSIGDLGARHLLERVAPSGG KVTVLTHCNTGALATAGYGT ALGVIRSLHSLGRLEHAFCT ETRPYNQGARLTAFELVYEQ IPATLITDSMVAAAMAHRG |
| Function | Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. |
| Protein Name | Methylthioribose-1-Phosphate IsomeraseM1piMtr-1-P IsomeraseMediator Of Rhoa-Dependent InvasionS-Methyl-5-Thioribose-1-Phosphate IsomeraseTranslation Initiation Factor Eif-2b Subunit Alpha/Beta/Delta-Like Protein |
| Database Links | Reactome: R-HSA-1237112 |
| Cellular Localisation | NucleusCytoplasmCell ProjectionPrimarily NuclearBut Cytoplasmic In Cancer CellsWith Enrichment At Leading Edge Of The Plasma Membrane In Late Stage Tumor Cells |
| Alternative Antibody Names | Anti-Methylthioribose-1-Phosphate Isomerase antibodyAnti-M1pi antibodyAnti-Mtr-1-P Isomerase antibodyAnti-Mediator Of Rhoa-Dependent Invasion antibodyAnti-S-Methyl-5-Thioribose-1-Phosphate Isomerase antibodyAnti-Translation Initiation Factor Eif-2b Subunit Alpha/Beta/Delta-Like Protein antibodyAnti-MRI1 antibodyAnti-MRDI antibodyAnti-UNQ6390 antibodyAnti-PRO21135 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and TWF2 knockout (KO) 293T cells, using [KO Validated] TWF2 Rabbit polyclonal antibody (STJ11100774) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89710/358192/STJ11100774_1__12392.1713122508.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and TWF2 knockout (KO) 293T cells, using [KO Validated] TWF2 Rabbit polyclonal antibody (STJ11100774) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.")