Anti-MRI1 antibody (1-369) (STJ116556)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MRI1 (1-369) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MRI1 |
| Gene ID | 84245 |
| Uniprot ID | MTNA_HUMAN |
| Immunogen Region | 1-369 |
| Immunogen Sequence | MTLEAIRYSRGSLQILDQLL LPKQSRYEAVGSVHQAWEAI RAMKVRGAPAIALVGCLSLA VELQAGAGGPGLAALVAFVR DKLSFLVTARPTAVNMARAA RDLADVAAREAEREGATEEA VRERVICCTEDMLEKDLRDN RSIGDLGARHLLERVAPSGG KVTVLTHCNTGALATAGYGT ALGVIRSLHSLGRLEHAFCT ETRPYNQGARLTAFELVYEQ IPATLITDSMVAAAMAHRG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-369 of human MRI1 (NP_001026897.1). |
Additional Info
| Function | Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. |
| Protein Name | Methylthioribose-1-Phosphate IsomeraseM1piMtr-1-P IsomeraseMediator Of Rhoa-Dependent InvasionS-Methyl-5-Thioribose-1-Phosphate IsomeraseTranslation Initiation Factor Eif-2b Subunit Alpha/Beta/Delta-Like Protein |
| Database Links | Reactome: R-HSA-1237112 |
| Cellular Localisation | NucleusCytoplasmCell ProjectionPrimarily NuclearBut Cytoplasmic In Cancer CellsWith Enrichment At Leading Edge Of The Plasma Membrane In Late Stage Tumor Cells |
| Alternative Antibody Names | Anti-Methylthioribose-1-Phosphate Isomerase antibodyAnti-M1pi antibodyAnti-Mtr-1-P Isomerase antibodyAnti-Mediator Of Rhoa-Dependent Invasion antibodyAnti-S-Methyl-5-Thioribose-1-Phosphate Isomerase antibodyAnti-Translation Initiation Factor Eif-2b Subunit Alpha/Beta/Delta-Like Protein antibodyAnti-MRI1 antibodyAnti-MRDI antibodyAnti-UNQ6390 antibodyAnti-PRO21135 antibody |
Information sourced from Uniprot.org