| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Melanocortin-2 receptor accessory protein 2 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MRAP2 |
| Gene ID: |
112609 |
| Uniprot ID: |
MRAP2_HUMAN |
| Specificity: |
This antibody detects endogenous levels of MRAP2 at Human |
| Immunogen: |
Synthesized peptide derived from human MRAP2 |
| Function | Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R).however, additional evidence is required in vivo. |
| Protein Name | Melanocortin-2 Receptor Accessory Protein 2Mc2r Accessory Protein 2 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinEndoplasmic Reticulum MembraneThe Formation Of Antiparallel Homo- And Heterodimers Suggest That N- And C-Terminus Can Both Localize In The Cytoplasmic And Extracellular PartsDepending On The Context |
| Alternative Antibody Names | Anti-Melanocortin-2 Receptor Accessory Protein 2 antibodyAnti-Mc2r Accessory Protein 2 antibodyAnti-MRAP2 antibodyAnti-C6orf117 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
