Anti-MRAP2 antibody (STJA0008458)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human MRAP2
General Information
| Short Description | Rabbit polyclonal anti-Melanocortin-2 receptor accessory protein 2 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MRAP2 |
| Gene ID | 112609 |
| Uniprot ID | MRAP2_HUMAN |
| Immunogen | Synthesized peptide derived from human MRAP2 |
| Specificity | This antibody detects endogenous levels of MRAP2 at Human |
Additional Info
| Function | Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R).however, additional evidence is required in vivo. |
| Protein Name | Melanocortin-2 Receptor Accessory Protein 2Mc2r Accessory Protein 2 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinEndoplasmic Reticulum MembraneThe Formation Of Antiparallel Homo- And Heterodimers Suggest That N- And C-Terminus Can Both Localize In The Cytoplasmic And Extracellular PartsDepending On The Context |
| Alternative Antibody Names | Anti-Melanocortin-2 Receptor Accessory Protein 2 antibodyAnti-Mc2r Accessory Protein 2 antibodyAnti-MRAP2 antibodyAnti-C6orf117 antibody |
Information sourced from Uniprot.org